Perfect trend system indicators12/22/2023 ![]() Viruses selected for antigenic characterization are a subset representing the genetic changes in the surface proteins seen in genetically characterized viruses. In HINT, viruses with similar antigenic properties have antibody neutralization titer differences of less than 8-fold. In HI assays, viruses with similar antigenic properties have antibody titer differences of less than or equal to 4-fold when compared to the reference (vaccine) virus. Ferret antisera are useful because antibodies raised against a particular virus can often recognize small changes in the surface proteins of other viruses. Antigenic differences between viruses are determined by comparing how well the antibodies made against the vaccine reference viruses recognize the circulating viruses that have been grown in cell culture. There are also prescription flu antiviral drugs that can be used to treat flu illness those need to be started as early as possible.ĬDC antigenically characterizes influenza viruses by hemagglutination inhibition (HI) (H1N1pdm09, B/Victoria, and B/Yamagata viruses) or neutralization-based HINT (H3N2 viruses) using antisera that ferrets make after being infected with reference viruses representing the 2022-2023 Northern Hemisphere recommended cell- or recombinant-based vaccine viruses.CDC continues to recommend that everyone ages 6 months and older get an annual flu vaccine as long as flu activity continues.All viruses collected and evaluated this season have been susceptible to the influenza antivirals peramivir, zanamivir, and baloxavir, and all viruses except for one (99.9%) have been susceptible to the influenza antiviral oseltamivir. ![]()
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